The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study
Identifieur interne : 006E73 ( Main/Exploration ); précédent : 006E72; suivant : 006E74The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study
Auteurs : Jean-Charles Lambert [France] ; Kristel Sleegers [Belgique] ; Antonio González-Pérez [Espagne] ; Martin Ingelsson [Suède] ; Gary W. Beecham [États-Unis] ; Mikko Hiltunen [Finlande] ; Onofre Combarros [Espagne] ; Maria J. Bullido [Espagne] ; Nathalie Brouwers [Belgique] ; Karolien Bettens [Belgique] ; Claudine Berr [France] ; Florence Pasquier [France] ; Florence Richard [France] ; Steven T. Dekosky [États-Unis] ; Didier Hannequin [France] ; Jonathan L. Haines [États-Unis] ; Gloria Tognoni [Italie] ; Nathalie Fiévet [France] ; Jean-François Dartigues [France] ; Christophe Tzourio [France] ; Sebastiaan Engelborghs [Belgique] ; Beatrice Arosio ; Elicer Coto [Espagne] ; Peter De Deyn [Belgique] ; Maria Del Zompo [Italie] ; Ignacio Mateo [Espagne] ; Merce Boada [Espagne] ; Carmen Antunez [Espagne] ; Jesus Lopez-Arrieta [Espagne] ; Jacques Epelbaum [France] ; Brit-Maren Michaud Schjeide [Allemagne] ; Ana Frank-Garcia [Espagne] ; Vilmentas Giedraitis [Suède] ; Seppo Helisalmi [Finlande] ; Elisa Porcellini [Italie] ; Alberto Pilotto [Italie] ; Paola Forti [Italie] ; Raffaele Ferri [Italie] ; Marc Delepine [France] ; Diana Zelenika [France] ; Mark Lathrop [France] ; Elio Scarpini [Italie] ; Gabriele Siciliano [Italie] ; Vincenzo Solfrizzi [Italie] ; Sandro Sorbi ; Gianfranco Spalletta ; Giovanni Ravaglia [Italie] ; Fernando Valdivieso [Espagne] ; Saila Veps L Inen [Finlande] ; Victoria Alvarez [Espagne] ; Paolo Bosco [Italie] ; Michelangelo Mancuso [Italie] ; Francesco Panza [Italie] ; Benedetta Nacmias [Italie] ; Paola Bossù ; Olivier Hanon [France] ; Paola Piccardi [Italie] ; Giorgio Annoni ; David Mann [Royaume-Uni] ; Philippe Marambaud [États-Unis] ; Davide Seripa [Italie] ; Daniela Galimberti [Italie] ; Rudolph E. Tanzi [États-Unis] ; Lars Bertram [Allemagne] ; Corinne Lendon [Australie] ; Lars Lannfelt [Suède] ; Federico Licastro [Italie] ; Dominique Campion [France] ; Margaret A. Pericak-Vance [États-Unis] ; Hilkka Soininen [Finlande] ; Christine Van Broeckhoven [Belgique] ; Annick Alpérovitch [France] ; Agustin Ruiz [Espagne] ; M Ilyas Kamboh [États-Unis] ; Philippe Amouyel [France]Source :
- Journal of Alzheimer's disease : JAD [ 1387-2877 ] ; 2010.
Abstract
The only established genetic determinant of non-Mendelian forms of Alzheimer’s disease (AD) is the ε4 allele of the apolipoprotein E gene (
Url:
DOI: 10.3233/JAD-2010-100933
PubMed: 20847397
PubMed Central: 2964875
Affiliations:
- Allemagne, Australie, Belgique, Espagne, Finlande, France, Italie, Royaume-Uni, Suède, États-Unis
- Angleterre, Berlin, Catalogne, Communauté de Madrid, Grand Manchester, Haute-Normandie, Hauts-de-France, Lombardie, Massachusetts, Nord-Pas-de-Calais, Pennsylvanie, Province d'Anvers, Région Normandie, Région flamande, Svealand, Toscane, Virginie, État de New York, Île-de-France
- Anvers, Barcelone, Berlin, Lille, Madrid, Manchester, Milan, Paris, Pise, Pittsburgh, Rouen, Stockholm, Évry (Essonne)
- Université Paris-Descartes, Université d'Anvers, Université de Manchester, Université de Pise, Université de Pittsburgh
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001498
- to stream Pmc, to step Curation: 001358
- to stream Pmc, to step Checkpoint: 002457
- to stream Ncbi, to step Merge: 000877
- to stream Ncbi, to step Curation: 000877
- to stream Ncbi, to step Checkpoint: 000877
- to stream Main, to step Merge: 007357
- to stream Main, to step Curation: 006E73
Le document en format XML
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Neocodex, Sevilla, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Structural Genomics. Neocodex, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation wicri:level="3"><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Uppsala University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation wicri:level="1"><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami</wicri:regionArea><wicri:noRegion>Miami</wicri:noRegion></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation wicri:level="1"><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Bullido, Maria J" sort="Bullido, Maria J" uniqKey="Bullido M" first="Maria J" last="Bullido">Maria J. Bullido</name><affiliation wicri:level="3"><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Brouwers, Nathalie" sort="Brouwers, Nathalie" uniqKey="Brouwers N" first="Nathalie" last="Brouwers">Nathalie Brouwers</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="1"><nlm:aff id="A12"> INSERM U888, Hôpital La Colombière, F-34093 Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U888, Hôpital La Colombière, F-34093 Montpellier</wicri:regionArea><wicri:noRegion>34093 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first="Florence" last="Richard">Florence Richard</name><affiliation wicri:level="1"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><wicri:noRegion>59019, Lille</wicri:noRegion><wicri:noRegion>59019, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université de Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><affiliation wicri:level="2"><nlm:aff id="A14"> University of Virginia School of medicine, Charlottesville, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> University of Virginia School of medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="3"><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="A16"> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Tognoni, Gloria" sort="Tognoni, Gloria" uniqKey="Tognoni G" first="Gloria" last="Tognoni">Gloria Tognoni</name><affiliation wicri:level="4"><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100</wicri:regionArea><orgName type="university">Université de Pise</orgName><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation wicri:level="1"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><wicri:noRegion>59019, Lille</wicri:noRegion><wicri:noRegion>59019, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="1"><nlm:aff id="A18"> INSERM U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><wicri:noRegion>33076, Bordeaux</wicri:noRegion><wicri:noRegion>33076, Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U708, F-75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><wicri:noRegion>75013 Paris</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ. Paris 06, F-75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><wicri:noRegion>75005 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Arosio, Beatrice" sort="Arosio, Beatrice" uniqKey="Arosio B" first="Beatrice" last="Arosio">Beatrice Arosio</name><affiliation><nlm:aff id="A22"> Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan Italy</nlm:aff><wicri:noCountry code="subfield">Milan Italy</wicri:noCountry></affiliation></author><author><name sortKey="Coto, Elicer" sort="Coto, Elicer" uniqKey="Coto E" first="Elicer" last="Coto">Elicer Coto</name><affiliation wicri:level="1"><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo</wicri:regionArea><wicri:noRegion>33006-Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="De Deyn, Peter" sort="De Deyn, Peter" uniqKey="De Deyn P" first="Peter" last="De Deyn">Peter De Deyn</name><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation wicri:level="1"><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari</wicri:regionArea><wicri:noRegion>University of Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation wicri:level="1"><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Merce" last="Boada">Merce Boada</name><affiliation wicri:level="3"><nlm:aff id="A25"> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26"> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Antunez, Carmen" sort="Antunez, Carmen" uniqKey="Antunez C" first="Carmen" last="Antunez">Carmen Antunez</name><affiliation wicri:level="1"><nlm:aff id="A27"> Alzheimur Foundation, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Alzheimur Foundation, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Arrieta, Jesus" sort="Lopez Arrieta, Jesus" uniqKey="Lopez Arrieta J" first="Jesus" last="Lopez-Arrieta">Jesus Lopez-Arrieta</name><affiliation wicri:level="3"><nlm:aff id="A29"> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Epelbaum, Jacques" sort="Epelbaum, Jacques" uniqKey="Epelbaum J" first="Jacques" last="Epelbaum">Jacques Epelbaum</name><affiliation wicri:level="4"><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Schjeide, Brit Maren Michaud" sort="Schjeide, Brit Maren Michaud" uniqKey="Schjeide B" first="Brit-Maren Michaud" last="Schjeide">Brit-Maren Michaud Schjeide</name><affiliation wicri:level="3"><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-Garcia">Ana Frank-Garcia</name><affiliation wicri:level="1"><nlm:aff id="A32"> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Giedraitis, Vilmentas" sort="Giedraitis, Vilmentas" uniqKey="Giedraitis V" first="Vilmentas" last="Giedraitis">Vilmentas Giedraitis</name><affiliation wicri:level="3"><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Uppsala University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Helisalmi, Seppo" sort="Helisalmi, Seppo" uniqKey="Helisalmi S" first="Seppo" last="Helisalmi">Seppo Helisalmi</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Porcellini, Elisa" sort="Porcellini, Elisa" uniqKey="Porcellini E" first="Elisa" last="Porcellini">Elisa Porcellini</name><affiliation wicri:level="1"><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Experimental Pathology, School of Medicine, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation wicri:level="1"><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013</wicri:regionArea><wicri:noRegion>I-71013</wicri:noRegion></affiliation></author><author><name sortKey="Forti, Paola" sort="Forti, Paola" uniqKey="Forti P" first="Paola" last="Forti">Paola Forti</name><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Ferri, Raffaele" sort="Ferri, Raffaele" uniqKey="Ferri R" first="Raffaele" last="Ferri">Raffaele Ferri</name><affiliation wicri:level="1"><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> IRCCS Oasi Maria SS, 94018 Troina </wicri:regionArea><wicri:noRegion>94018 Troina </wicri:noRegion></affiliation></author><author><name sortKey="Delepine, Marc" sort="Delepine, Marc" uniqKey="Delepine M" first="Marc" last="Delepine">Marc Delepine</name><affiliation wicri:level="3"><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation wicri:level="3"><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="3"><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A38"> Fondation Jean Dausset-CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Fondation Jean Dausset-CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="3"><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><affiliation wicri:level="1"><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari</wicri:regionArea><wicri:noRegion>70124 Bari</wicri:noRegion></affiliation></author><author><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><affiliation wicri:level="1"><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neurological and Psychiatric Sciences, 50134 Florence</wicri:regionArea><wicri:noRegion>50134 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff><wicri:noCountry code="subfield">00179 Roma – Italy</wicri:noCountry></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff><wicri:noCountry code="subfield">Monza Italy</wicri:noCountry></affiliation></author><author><name sortKey="Ravaglia, Giovanni" sort="Ravaglia, Giovanni" uniqKey="Ravaglia G" first="Giovanni" last="Ravaglia">Giovanni Ravaglia</name><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Valdivieso, Fernando" sort="Valdivieso, Fernando" uniqKey="Valdivieso F" first="Fernando" last="Valdivieso">Fernando Valdivieso</name><affiliation wicri:level="3"><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Veps L Inen, Saila" sort="Veps L Inen, Saila" uniqKey="Veps L Inen S" first="Saila" last="Veps L Inen">Saila Veps L Inen</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation wicri:level="1"><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo</wicri:regionArea><wicri:noRegion>33006-Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation wicri:level="1"><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> IRCCS Oasi Maria SS, 94018 Troina </wicri:regionArea><wicri:noRegion>94018 Troina </wicri:noRegion></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation wicri:level="4"><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100</wicri:regionArea><orgName type="university">Université de Pise</orgName><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation wicri:level="1"><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari</wicri:regionArea><wicri:noRegion>70124 Bari</wicri:noRegion></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation wicri:level="1"><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neurological and Psychiatric Sciences, 50134 Florence</wicri:regionArea><wicri:noRegion>50134 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff><wicri:noCountry code="subfield">00179 Roma – Italy</wicri:noCountry></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation wicri:level="4"><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Piccardi, Paola" sort="Piccardi, Paola" uniqKey="Piccardi P" first="Paola" last="Piccardi">Paola Piccardi</name><affiliation wicri:level="1"><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari</wicri:regionArea><wicri:noRegion>University of Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Annoni, Giorgio" sort="Annoni, Giorgio" uniqKey="Annoni G" first="Giorgio" last="Annoni">Giorgio Annoni</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff><wicri:noCountry code="subfield">Monza Italy</wicri:noCountry></affiliation></author><author><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name><affiliation wicri:level="4"><nlm:aff id="A44"> Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Greater Manchester Neuroscience Centre, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Marambaud, Philippe" sort="Marambaud, Philippe" uniqKey="Marambaud P" first="Philippe" last="Marambaud">Philippe Marambaud</name><affiliation wicri:level="2"><nlm:aff id="A45"> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A46"> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name><affiliation wicri:level="1"><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013</wicri:regionArea><wicri:noRegion>I-71013</wicri:noRegion></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tanzi, Rudolph E" sort="Tanzi, Rudolph E" uniqKey="Tanzi R" first="Rudolph E" last="Tanzi">Rudolph E. Tanzi</name><affiliation wicri:level="2"><nlm:aff id="A47"> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown</wicri:cityArea></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation wicri:level="1"><nlm:aff id="A48"> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029</wicri:regionArea><wicri:noRegion>Queensland 4029</wicri:noRegion></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation wicri:level="3"><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Uppsala University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Licastro, Federico" sort="Licastro, Federico" uniqKey="Licastro F" first="Federico" last="Licastro">Federico Licastro</name><affiliation wicri:level="1"><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Experimental Pathology, School of Medicine, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="3"><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="1"><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami</wicri:regionArea><wicri:noRegion>Miami</wicri:noRegion></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation wicri:level="3"><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U708, F-75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ. Paris 06, F-75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation wicri:level="1"><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Structural Genomics. Neocodex, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation wicri:level="4"><nlm:aff id="A49"> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université de Lille Nord de France, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20847397</idno><idno type="pmc">2964875</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964875</idno><idno type="RBID">PMC:2964875</idno><idno type="doi">10.3233/JAD-2010-100933</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001498</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001498</idno><idno type="wicri:Area/Pmc/Curation">001358</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001358</idno><idno type="wicri:Area/Pmc/Checkpoint">002457</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002457</idno><idno type="wicri:Area/Ncbi/Merge">000877</idno><idno type="wicri:Area/Ncbi/Curation">000877</idno><idno type="wicri:Area/Ncbi/Checkpoint">000877</idno><idno type="wicri:Area/Main/Merge">007357</idno><idno type="wicri:Area/Main/Curation">006E73</idno><idno type="wicri:Area/Main/Exploration">006E73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>CALHM1</italic> P86L polymorphism is a genetic modifier of age at onset in Alzheimer’s disease: a meta-analysis study</title><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université de Lille Nord de France, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Gonzalez Perez, Antonio" sort="Gonzalez Perez, Antonio" uniqKey="Gonzalez Perez A" first="Antonio" last="González-Pérez">Antonio González-Pérez</name><affiliation wicri:level="1"><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Structural Genomics. Neocodex, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation wicri:level="3"><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Uppsala University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name><affiliation wicri:level="1"><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami</wicri:regionArea><wicri:noRegion>Miami</wicri:noRegion></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation wicri:level="1"><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Bullido, Maria J" sort="Bullido, Maria J" uniqKey="Bullido M" first="Maria J" last="Bullido">Maria J. Bullido</name><affiliation wicri:level="3"><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Brouwers, Nathalie" sort="Brouwers, Nathalie" uniqKey="Brouwers N" first="Nathalie" last="Brouwers">Nathalie Brouwers</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="1"><nlm:aff id="A12"> INSERM U888, Hôpital La Colombière, F-34093 Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U888, Hôpital La Colombière, F-34093 Montpellier</wicri:regionArea><wicri:noRegion>34093 Montpellier</wicri:noRegion><wicri:noRegion>34093 Montpellier</wicri:noRegion></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="1"><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université de Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><affiliation wicri:level="1"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><wicri:noRegion>59019, Lille</wicri:noRegion><wicri:noRegion>59019, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université de Lille Nord de France, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU de Lille, F-59000 Lille</wicri:regionArea><wicri:noRegion>59000 Lille</wicri:noRegion><wicri:noRegion>59000 Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><affiliation wicri:level="2"><nlm:aff id="A14"> University of Virginia School of medicine, Charlottesville, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> University of Virginia School of medicine, Charlottesville, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="3"><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="A16"> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Vanderbilt Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Tognoni, Gloria" sort="Tognoni, Gloria" uniqKey="Tognoni G" first="Gloria" last="Tognoni">Gloria Tognoni</name><affiliation wicri:level="4"><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100</wicri:regionArea><orgName type="university">Université de Pise</orgName><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation wicri:level="1"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><wicri:noRegion>59019 Lille</wicri:noRegion><wicri:noRegion>59019 Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><wicri:noRegion>59019, Lille</wicri:noRegion><wicri:noRegion>59019, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="1"><nlm:aff id="A18"> INSERM U897, Victor Segalen University, F-33076, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><wicri:noRegion>33076, Bordeaux</wicri:noRegion><wicri:noRegion>33076, Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U708, F-75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><wicri:noRegion>75013 Paris</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ. Paris 06, F-75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><wicri:noRegion>75005 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Arosio, Beatrice" sort="Arosio, Beatrice" uniqKey="Arosio B" first="Beatrice" last="Arosio">Beatrice Arosio</name><affiliation><nlm:aff id="A22"> Department of Internal Medicine, Fondazione Policlinico IRCCS, Milan Italy</nlm:aff><wicri:noCountry code="subfield">Milan Italy</wicri:noCountry></affiliation></author><author><name sortKey="Coto, Elicer" sort="Coto, Elicer" uniqKey="Coto E" first="Elicer" last="Coto">Elicer Coto</name><affiliation wicri:level="1"><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo</wicri:regionArea><wicri:noRegion>33006-Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="De Deyn, Peter" sort="De Deyn, Peter" uniqKey="De Deyn P" first="Peter" last="De Deyn">Peter De Deyn</name><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A21"> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Memory Clinic and Department of Neurology, ZNA Middelheim, Antwerpen</wicri:regionArea><wicri:noRegion>Antwerpen</wicri:noRegion></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation wicri:level="1"><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari</wicri:regionArea><wicri:noRegion>University of Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation wicri:level="1"><nlm:aff id="A10"> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Neurology Service and CIBERNED, “Marqués de Valdecilla” University Hospital (University of Cantabria), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Merce" last="Boada">Merce Boada</name><affiliation wicri:level="3"><nlm:aff id="A25"> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26"> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Neurology Department, Hospital G. Universitari Vall d’Hebron, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Antunez, Carmen" sort="Antunez, Carmen" uniqKey="Antunez C" first="Carmen" last="Antunez">Carmen Antunez</name><affiliation wicri:level="1"><nlm:aff id="A27"> Alzheimur Foundation, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Alzheimur Foundation, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Dementia Unit. University Hospital Virgen de la Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Arrieta, Jesus" sort="Lopez Arrieta, Jesus" uniqKey="Lopez Arrieta J" first="Jesus" last="Lopez-Arrieta">Jesus Lopez-Arrieta</name><affiliation wicri:level="3"><nlm:aff id="A29"> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Memory Unit. University Hospital La Paz- Cantoblanco, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Epelbaum, Jacques" sort="Epelbaum, Jacques" uniqKey="Epelbaum J" first="Jacques" last="Epelbaum">Jacques Epelbaum</name><affiliation wicri:level="4"><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Schjeide, Brit Maren Michaud" sort="Schjeide, Brit Maren Michaud" uniqKey="Schjeide B" first="Brit-Maren Michaud" last="Schjeide">Brit-Maren Michaud Schjeide</name><affiliation wicri:level="3"><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-Garcia">Ana Frank-Garcia</name><affiliation wicri:level="1"><nlm:aff id="A32"> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Servicio de Neurologia, Hospital Universitario La Paz (UAM) and CIBERNED, 28034 Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Giedraitis, Vilmentas" sort="Giedraitis, Vilmentas" uniqKey="Giedraitis V" first="Vilmentas" last="Giedraitis">Vilmentas Giedraitis</name><affiliation wicri:level="3"><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Uppsala University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Helisalmi, Seppo" sort="Helisalmi, Seppo" uniqKey="Helisalmi S" first="Seppo" last="Helisalmi">Seppo Helisalmi</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Porcellini, Elisa" sort="Porcellini, Elisa" uniqKey="Porcellini E" first="Elisa" last="Porcellini">Elisa Porcellini</name><affiliation wicri:level="1"><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Experimental Pathology, School of Medicine, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation wicri:level="1"><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013</wicri:regionArea><wicri:noRegion>I-71013</wicri:noRegion></affiliation></author><author><name sortKey="Forti, Paola" sort="Forti, Paola" uniqKey="Forti P" first="Paola" last="Forti">Paola Forti</name><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Ferri, Raffaele" sort="Ferri, Raffaele" uniqKey="Ferri R" first="Raffaele" last="Ferri">Raffaele Ferri</name><affiliation wicri:level="1"><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> IRCCS Oasi Maria SS, 94018 Troina </wicri:regionArea><wicri:noRegion>94018 Troina </wicri:noRegion></affiliation></author><author><name sortKey="Delepine, Marc" sort="Delepine, Marc" uniqKey="Delepine M" first="Marc" last="Delepine">Marc Delepine</name><affiliation wicri:level="3"><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation wicri:level="3"><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="3"><nlm:aff id="A37"> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Centre National de Genotypage, Institut Genomique, Commissariat à l’Énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A38"> Fondation Jean Dausset-CEPH, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Fondation Jean Dausset-CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="3"><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><affiliation wicri:level="1"><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari</wicri:regionArea><wicri:noRegion>70124 Bari</wicri:noRegion></affiliation></author><author><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><affiliation wicri:level="1"><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neurological and Psychiatric Sciences, 50134 Florence</wicri:regionArea><wicri:noRegion>50134 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff><wicri:noCountry code="subfield">00179 Roma – Italy</wicri:noCountry></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff><wicri:noCountry code="subfield">Monza Italy</wicri:noCountry></affiliation></author><author><name sortKey="Ravaglia, Giovanni" sort="Ravaglia, Giovanni" uniqKey="Ravaglia G" first="Giovanni" last="Ravaglia">Giovanni Ravaglia</name><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Internal Medicine Cardiology and Hepatology, University Hospital S. Orsola-Malpighi, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Valdivieso, Fernando" sort="Valdivieso, Fernando" uniqKey="Valdivieso F" first="Fernando" last="Valdivieso">Fernando Valdivieso</name><affiliation wicri:level="3"><nlm:aff id="A11"> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Biologia Molecular Severo Ochoa (UAM-CSIC) and CIBERNED, Universidad Autonoma, Cantoblanco, S-28049, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Veps L Inen, Saila" sort="Veps L Inen, Saila" uniqKey="Veps L Inen S" first="Saila" last="Veps L Inen">Saila Veps L Inen</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation wicri:level="1"><nlm:aff id="A23"> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Genetic Molecular Unit, Hospital Universitario Central de Asturias, 33006-Oviedo</wicri:regionArea><wicri:noRegion>33006-Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation wicri:level="1"><nlm:aff id="A36"> IRCCS Oasi Maria SS, 94018 Troina , Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> IRCCS Oasi Maria SS, 94018 Troina </wicri:regionArea><wicri:noRegion>94018 Troina </wicri:noRegion></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation wicri:level="4"><nlm:aff id="A17"> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neuroscience, Neurological Clinic, University of Pisa, I-56100</wicri:regionArea><orgName type="university">Université de Pise</orgName><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation wicri:level="1"><nlm:aff id="A40"> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, 70124 Bari</wicri:regionArea><wicri:noRegion>70124 Bari</wicri:noRegion></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation wicri:level="1"><nlm:aff id="A41"> Department of Neurological and Psychiatric Sciences, 50134 Florence, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Neurological and Psychiatric Sciences, 50134 Florence</wicri:regionArea><wicri:noRegion>50134 Florence</wicri:noRegion></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation><nlm:aff id="A42"> Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 00179 Roma – Italy</nlm:aff><wicri:noCountry code="subfield">00179 Roma – Italy</wicri:noCountry></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation wicri:level="4"><nlm:aff id="A30"> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UMR 894, INSERM Faculté de Médecine, Université Paris Descartes, F-75014 Paris</wicri:regionArea><wicri:noRegion>75014 Paris</wicri:noRegion><orgName type="university">Université Paris-Descartes</orgName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Piccardi, Paola" sort="Piccardi, Paola" uniqKey="Piccardi P" first="Paola" last="Piccardi">Paola Piccardi</name><affiliation wicri:level="1"><nlm:aff id="A24"> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Section of Clinical Pharmacology, Department of Neuroscience, University of Cagliari</wicri:regionArea><wicri:noRegion>University of Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Annoni, Giorgio" sort="Annoni, Giorgio" uniqKey="Annoni G" first="Giorgio" last="Annoni">Giorgio Annoni</name><affiliation><nlm:aff id="A43"> Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Monza Italy</nlm:aff><wicri:noCountry code="subfield">Monza Italy</wicri:noCountry></affiliation></author><author><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name><affiliation wicri:level="4"><nlm:aff id="A44"> Greater Manchester Neuroscience Centre, University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Greater Manchester Neuroscience Centre, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Marambaud, Philippe" sort="Marambaud, Philippe" uniqKey="Marambaud P" first="Philippe" last="Marambaud">Philippe Marambaud</name><affiliation wicri:level="2"><nlm:aff id="A45"> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Litwin-Zucker Research Center for the Study of Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A46"> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Pathology, Albert Einstein College of Medicine, Bronx, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name><affiliation wicri:level="1"><nlm:aff id="A34"> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Geriatric Unit & Gerontology-Geriatric Research Laboratory, Department of Medical Science, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo , I-71013</wicri:regionArea><wicri:noRegion>I-71013</wicri:noRegion></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><nlm:aff id="A39"> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept. of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tanzi, Rudolph E" sort="Tanzi, Rudolph E" uniqKey="Tanzi R" first="Rudolph E" last="Tanzi">Rudolph E. Tanzi</name><affiliation wicri:level="2"><nlm:aff id="A47"> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown, MA 02129</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea> Genetics and Aging Research Unit, Massachusetts General Hospital, Charlestown</wicri:cityArea></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:aff id="A31"> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation wicri:level="1"><nlm:aff id="A48"> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Molecular Psychiatry Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029</wicri:regionArea><wicri:noRegion>Queensland 4029</wicri:noRegion></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation wicri:level="3"><nlm:aff id="A7"> Uppsala University, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Uppsala University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Licastro, Federico" sort="Licastro, Federico" uniqKey="Licastro F" first="Federico" last="Licastro">Federico Licastro</name><affiliation wicri:level="1"><nlm:aff id="A33"> Department of Experimental Pathology, School of Medicine, University of Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Experimental Pathology, School of Medicine, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="1"><nlm:aff id="A15"> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U614, Faculté de Médecine-Pharmacie de Rouen, F-76183, Rouen</wicri:regionArea><wicri:noRegion>76183, Rouen</wicri:noRegion><wicri:noRegion>76183, Rouen</wicri:noRegion></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="1"><nlm:aff id="A8"> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami</wicri:regionArea><wicri:noRegion>Miami</wicri:noRegion></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="A9"> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Department of Neurology, Kuopio University and University Hospital, 70211, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="1"><nlm:aff id="A4"> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A5"> Institute Born-Bunge and University of Antwerp, Antwerp, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> Institute Born-Bunge and University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation wicri:level="1"><nlm:aff id="A19"> INSERM U708, F-75013 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U708, F-75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><wicri:noRegion>75013 Paris</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A20"> UPMC Univ. Paris 06, F-75005 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ. Paris 06, F-75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><wicri:noRegion>75005 Paris</wicri:noRegion></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation wicri:level="1"><nlm:aff id="A6"> Department of Structural Genomics. Neocodex, Sevilla, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Structural Genomics. Neocodex, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><affiliation wicri:level="4"><nlm:aff id="A49"> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Human Genetics and Alzheimer's Disease Research Centre, University of Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM U744, F-59019 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, F-59019 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> Institut Pasteur de Lille, F-59019, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Institut Pasteur de Lille, F-59019, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3"> Université de Lille Nord de France, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université de Lille Nord de France, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A13"> CHRU de Lille, F-59000 Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU de Lille, F-59000 Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's disease : JAD</title><idno type="ISSN">1387-2877</idno><idno type="eISSN">1875-8908</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The only established genetic determinant of non-Mendelian forms of Alzheimer’s disease (AD) is the ε4 allele of the apolipoprotein E gene (<italic>APOE</italic>). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (<italic>CALHM1</italic>) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centres in Belgium, Finland, France, Italy, Spain, Sweden, the UK and the USA). Our results indicate that the <italic>CALHM1</italic> P86L polymorphism is likely not a genetic determinant of AD but may modulate age at onset by interacting with the effect of the ε4 allele of the <italic>APOE</italic> gene.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Berlin</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Grand Manchester</li><li>Haute-Normandie</li><li>Hauts-de-France</li><li>Lombardie</li><li>Massachusetts</li><li>Nord-Pas-de-Calais</li><li>Pennsylvanie</li><li>Province d'Anvers</li><li>Région Normandie</li><li>Région flamande</li><li>Svealand</li><li>Toscane</li><li>Virginie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Barcelone</li><li>Berlin</li><li>Lille</li><li>Madrid</li><li>Manchester</li><li>Milan</li><li>Paris</li><li>Pise</li><li>Pittsburgh</li><li>Rouen</li><li>Stockholm</li><li>Évry (Essonne)</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université d'Anvers</li><li>Université de Manchester</li><li>Université de Pise</li><li>Université de Pittsburgh</li></orgName></list><tree><noCountry><name sortKey="Annoni, Giorgio" sort="Annoni, Giorgio" uniqKey="Annoni G" first="Giorgio" last="Annoni">Giorgio Annoni</name><name sortKey="Arosio, Beatrice" sort="Arosio, Beatrice" uniqKey="Arosio B" first="Beatrice" last="Arosio">Beatrice Arosio</name><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name></noCountry><country name="France"><region name="Hauts-de-France"><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></region><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Delepine, Marc" sort="Delepine, Marc" uniqKey="Delepine M" first="Marc" last="Delepine">Marc Delepine</name><name sortKey="Epelbaum, Jacques" sort="Epelbaum, Jacques" uniqKey="Epelbaum J" first="Jacques" last="Epelbaum">Jacques Epelbaum</name><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name></country><country name="Belgique"><noRegion><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name></noRegion><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><name sortKey="Brouwers, Nathalie" sort="Brouwers, Nathalie" uniqKey="Brouwers N" first="Nathalie" last="Brouwers">Nathalie Brouwers</name><name sortKey="Brouwers, Nathalie" sort="Brouwers, Nathalie" uniqKey="Brouwers N" first="Nathalie" last="Brouwers">Nathalie Brouwers</name><name sortKey="De Deyn, Peter" sort="De Deyn, Peter" uniqKey="De Deyn P" first="Peter" last="De Deyn">Peter De Deyn</name><name sortKey="De Deyn, Peter" sort="De Deyn, Peter" uniqKey="De Deyn P" first="Peter" last="De Deyn">Peter De Deyn</name><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name></country><country name="Espagne"><noRegion><name sortKey="Gonzalez Perez, Antonio" sort="Gonzalez Perez, Antonio" uniqKey="Gonzalez Perez A" first="Antonio" last="González-Pérez">Antonio González-Pérez</name></noRegion><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><name sortKey="Antunez, Carmen" sort="Antunez, Carmen" uniqKey="Antunez C" first="Carmen" last="Antunez">Carmen Antunez</name><name sortKey="Antunez, Carmen" sort="Antunez, Carmen" uniqKey="Antunez C" first="Carmen" last="Antunez">Carmen Antunez</name><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Merce" last="Boada">Merce Boada</name><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Merce" last="Boada">Merce Boada</name><name sortKey="Bullido, Maria J" sort="Bullido, Maria J" uniqKey="Bullido M" first="Maria J" last="Bullido">Maria J. Bullido</name><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><name sortKey="Coto, Elicer" sort="Coto, Elicer" uniqKey="Coto E" first="Elicer" last="Coto">Elicer Coto</name><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-Garcia">Ana Frank-Garcia</name><name sortKey="Lopez Arrieta, Jesus" sort="Lopez Arrieta, Jesus" uniqKey="Lopez Arrieta J" first="Jesus" last="Lopez-Arrieta">Jesus Lopez-Arrieta</name><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><name sortKey="Valdivieso, Fernando" sort="Valdivieso, Fernando" uniqKey="Valdivieso F" first="Fernando" last="Valdivieso">Fernando Valdivieso</name></country><country name="Suède"><region name="Svealand"><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name></region><name sortKey="Giedraitis, Vilmentas" sort="Giedraitis, Vilmentas" uniqKey="Giedraitis V" first="Vilmentas" last="Giedraitis">Vilmentas Giedraitis</name><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name></country><country name="États-Unis"><noRegion><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W" last="Beecham">Gary W. Beecham</name></noRegion><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M Ilyas" last="Kamboh">M Ilyas Kamboh</name><name sortKey="Marambaud, Philippe" sort="Marambaud, Philippe" uniqKey="Marambaud P" first="Philippe" last="Marambaud">Philippe Marambaud</name><name sortKey="Marambaud, Philippe" sort="Marambaud, Philippe" uniqKey="Marambaud P" first="Philippe" last="Marambaud">Philippe Marambaud</name><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A" last="Pericak-Vance">Margaret A. Pericak-Vance</name><name sortKey="Tanzi, Rudolph E" sort="Tanzi, Rudolph E" uniqKey="Tanzi R" first="Rudolph E" last="Tanzi">Rudolph E. Tanzi</name></country><country name="Finlande"><noRegion><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name></noRegion><name sortKey="Helisalmi, Seppo" sort="Helisalmi, Seppo" uniqKey="Helisalmi S" first="Seppo" last="Helisalmi">Seppo Helisalmi</name><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><name sortKey="Veps L Inen, Saila" sort="Veps L Inen, Saila" uniqKey="Veps L Inen S" first="Saila" last="Veps L Inen">Saila Veps L Inen</name></country><country name="Italie"><region name="Toscane"><name sortKey="Tognoni, Gloria" sort="Tognoni, Gloria" uniqKey="Tognoni G" first="Gloria" last="Tognoni">Gloria Tognoni</name></region><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><name sortKey="Ferri, Raffaele" sort="Ferri, Raffaele" uniqKey="Ferri R" first="Raffaele" last="Ferri">Raffaele Ferri</name><name sortKey="Forti, Paola" sort="Forti, Paola" uniqKey="Forti P" first="Paola" last="Forti">Paola Forti</name><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><name sortKey="Licastro, Federico" sort="Licastro, Federico" uniqKey="Licastro F" first="Federico" last="Licastro">Federico Licastro</name><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><name sortKey="Piccardi, Paola" sort="Piccardi, Paola" uniqKey="Piccardi P" first="Paola" last="Piccardi">Paola Piccardi</name><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><name sortKey="Porcellini, Elisa" sort="Porcellini, Elisa" uniqKey="Porcellini E" first="Elisa" last="Porcellini">Elisa Porcellini</name><name sortKey="Ravaglia, Giovanni" sort="Ravaglia, Giovanni" uniqKey="Ravaglia G" first="Giovanni" last="Ravaglia">Giovanni Ravaglia</name><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Schjeide, Brit Maren Michaud" sort="Schjeide, Brit Maren Michaud" uniqKey="Schjeide B" first="Brit-Maren Michaud" last="Schjeide">Brit-Maren Michaud Schjeide</name></region><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mann, David" sort="Mann, David" uniqKey="Mann D" first="David" last="Mann">David Mann</name></region></country><country name="Australie"><noRegion><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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